brainmetsbc.org

Center of Excellence Publications, Abstracts and Presentations

Publications 

Palmieri, D., Smith, Q.R., Lockman, P.R., Bronder, J.L., Gril, B., Ahmad, A., Chambers, A.F., Weil, R. J. and Steeg, P.S.: Brain metastasis of breast cancer. Breast Diseases. 26:139-147, 2007.  

Palmieri, D., Chambers, A.F., Felding-Haberman, B., Huang, S. and Steeg, P.S.: The biology of metastasis to a sanctuary site. Clin. Cancer Res. 13: 1656-1662, 2007. 

Palmieri, D., Bronder, J.L., Herring, J.M., Yoneda, T., Weil, R.J., Stark, A.M., Kurek, R., Vega-Valle, E., Feigenbaum, L., Vortmeyer, A.O., Aldape, K. and Steeg, P.S.: Her-2 overexpression increases the metastatic outgrowth of breast cancer cells in the brain. Cancer Res. 67:4190-4198, 2007.  

Heyn, C., Ronald, J.A., Ramadan, S. S., MacKenzie, L.T., Mikulis, D.J., Palmieri, D., Bronder, J.L., Steeg, P.S., Yoneda, T., MacDonald, I.C., Chambers, A.F., Rutt, B.K. and Foster, P.J.: In vivo tracking of growth and dormancy of solitary cells in a mouse model of breast cancer metastasis to the brain using MRI. Mag. Reson. Med. 56: 1001-1010, 2006.  

Mayer, M.: A patient perspective on brain metastases in breast cancer. Clin. Cancer Res. 13: 1623-1624, 2007. 

Muldoon LL, Soussain C, Jahnke K, Johanson C, Siegal T, Smith QR, Hall WA, Hynynen K, Senter PD, Peereboom DM, Neuwelt EA. Chemotherapy delivery issues in central nervous system malignancy: a reality check. J Clin Oncol. 25(16):2295-305, 2007.   

Abstracts 

Taskar K, Mittapalli RK, Rudraraju V, Egbert JA, Bohn KA, Gaasch JA, Thomas F, Lockman PR and Smith QR. Improved Left Ventricle Intracardiac injection method for brain metastases of breast cancer in immune compromised mice.  Society for Neuroscience Annual Meeting. San Diego, CA.  2007. 

Thomas F, Rudraraju V, Lockman PR and Smith QR Blood brain barrier permeability and transport of temozolomide.  The American Association of Pharmaceutical Scientists, Annual Meeting. San Diego, CA. 2007. 

Mittapalli RK, Manda VK, Smith QR and Lockman PR. Permeability of the fluorophore Texas red is not subject to MRP-2 mediated efflux at the blood-brain barrier. The American Association of Pharmaceutical Scientists, Annual Meeting. San Diego, CA. 2007.

Mittapalli RK, Fitzgerald A, Manda VK and Lockman PR. A computational approach topredict the blood-brain permeability of fluorescent dyes. The American Association of Pharmaceutical Scientists, Annual Meeting.  San Diego, CA. 2007. 

Heyn C, Ronald JA, Ramadan SS, Snir JA, Barry AM, MacKenzie LT, Mikulis DJ, Palmieri D, Bronder JL, Steeg PS, Yoneda T, MacDonald IC, Chambers AF, Rutt BK, Foster PJ. In vivo tracking of growth and dormancy of solitary cells in a mouse model of breast cancer metastasis to brain using MRI. 14th Scientific Meeting & Exhibition of the International Society for Magnetic Resonance in Medicine, Seattle,WA. 2006. 

Ramadan S, Heyn C, Rutt B, Foster P. Single cell MRI with FIESTA:quantitative benefits of 3T vs. 1.5T. 14th Scientific Meeting & Exhibition of the International Society for Magnetic Resonance in Medicine, Seattle, WA. 2006.  

Ramadan S, MacKenzie L, Steeg P, Palmieri D, Chambers A, Rutt B, Foster P. In-vivo MR tracking of solitary cells as a tool for comparing the metastatic behaviour of two distinct breast cancer cell lines. Imaging Network Ontario 6th Imaging Symposium, Toronto, ON, Canada. 2007.  

Ramadan SS, MacKenzie LT, Steeg PS, Chambers AF, Rutt BK, Foster PJ. In vivo tracking of solitary cells as a tool for comparing the behaviour of two metastatically-distinct cell lines in a mouse model of breast cancer metastasis to the brain. 15th Scientific Meeting & Exhibition of the International Society for Magnetic Resonance in Medicine, Berlin, Germany. 2007. 

Irene F. Newsham and Janet E. Price. Dissecting the extravasation process of metastatic breast cancer cells using an Electric Cell- Substrate Impedance Sensing (ECIS) assay. Metastasis Research Society Meeting, 2006. 

Diane Palmieri, Julie L. Bronder, Robert J. Weil, Andreas Stark, Sean Davis, Eleazar Vega-Valle, Jeanne Herring, Toshiyuki Yoneda, Raffael Kurek, H. Maximilian Mehdorn, Paul S. Meltzer, Patricia S. Steeg. Preclinical studies in support of the use of Vorinostat (SAHA) for the treatment of brain metastases of breast cancer. American Association of Cancer Research Annual Meeting. Los Angeles, CA. 2007 

Daniel P. Fitzgerald, Diane Palmieri, Eleazar Vega-Valle, Jeanne Herring, Patricia S. Steeg. A xenograft model of brain metastasis of breast cancer: metastatic tumors and the brain microenvironment . American Association of Cancer Research Annual Meeting.Los Angeles, CA. 2007 

Brunilde M. Gril, Diane Palmieri, Elezar Vega-Valle, Emily K. Hua, Jeanne Herring, Tona M. Gilmer, Stephen D. Rubin, Patricia S. Steeg.  Lapatinib Prevents the Metastatic Colonization of EGFR+ and Her-2+ Breast Cancer Cells in the Brain. American Association of Cancer Research Annual Meeting. Los Angeles, CA. 2007. 

Matthew A. Hunt, Leslie L. Muldoon, Diane Palmieri, Patricia S. Steeg, Edward A. Neuwelt ‚ÄúHER-2 status influences survival in a rat model of brain metastasis from breast cancer‚ÄĚ.¬† Annual Blood-Brain Barrier Consortium Meeting. Skamania Lodge, WA. 2007.And American Association of Cancer Research Annual Meeting. Los Angeles, CA. 2007.¬†

Brogi, E., Murray, M.P., Nehhozina, T., Akram, M., Cranor, M., Seidman, A. Clinical and pathologic characteristics of brain metastases of breast carcinoma: A study of 74 patients. San Antonio Breast Cancer Symposium, San Antonio, TX. 2006. 

Presentations 

Patricia Steeg, ‚ÄúA molecular portrait of breast cancer metastasis to the brain‚ÄĚ. Ruth Sager Memorial Lecture, Boston Cancer Research Association. April 2007.¬†

Patricia Steeg, ‚ÄúBrain metastases of breast cancer‚ÄĚ. Keynote speaker, Ben May Institute for Cancer Research, University of Chicago. Cancer Research Symposium on Frontiers in Metastasis Research. October 2006.¬†

Patricia Steeg, ‚ÄúThe role of Her-2 in brain metastasis‚ÄĚ. Invited speaker, BRESCOM Breast cancer and metastasis conference. Paris, France. June 2006.¬†

Patricia Steeg, ‚ÄúNew molecular targets for metastatic breast cancer‚ÄĚ. Invited speaker, Metastatic Breast Cancer Network, New York, NY. October 2006.¬†

Quentin Smith, ‚ÄúTumors and the Blood-Brain Barrier‚ÄĚ 13th Annual Blood-Brain Barrier Consortium Meeting. Sevenson, WA. March 2007.¬†

Quentin Smith, ‚ÄúBrain Drug Delivery through Carrier-Mediated Transport‚ÄĚ 18th Annual Spring Brain Conference. Sedona, Arizona. March 2007.¬†

Paul Lockman, ‚ÄúDrug delivery across the blood-tumor barrier.‚ÄĚ Invited Seminar, The University of Texas, MD. Anderson Cancer Center, Cancer Biology Seminar Series. Houston, Tx. February, 2007.¬†

Paul Lockman, ‚ÄúPermeability at the blood-tumor barrier.‚ÄĚ Invited Seminar, Northeastern Ohio University, Colleges of Medicine, Akron, Ohio. 2007.¬†

Ann Chambers, ‚ÄúDormancy and Growth of Tumor Cells in Ectopic Sites‚ÄĚ. Invited speaker, Educational Session on ‚ÄėInvasion and Metastasis‚Äô. American Association for Cancer Research 97th Annual Meeting, Washington, DC, April 2006.¬†¬†

Ann Chambers, ‚ÄúBiology of Tumor Metastasis and Clinical Implications‚ÄĚ. Invited speaker, McGill Cancer Group Seminar Series, McGill University, Montreal, Quebec, Canada, April 2006.¬†¬†

Ann Chambers, ‚ÄúTumor Metastasis: Mouse Models and Preclinical Imaging‚ÄĚ. Invited speaker, Lawson Imaging Seminar Series, London, Ontario, Canada. April 2006.¬†

Ann Chambers, ‚ÄúBreast Cancer Metastasis‚ÄĚ. Invited speaker, EMBO Conference on Common Molecular Mechanisms of Mammary Gland Development and Breast Cancer Progression. Dublin, Ireland. June 2006.¬†Ann Chambers, ‚ÄúImaging the metastatic process in experimental models and clinicalimplications‚ÄĚ.

Invited workshop participant, National Cancer Institutes, NIH, ‚ÄėTumor Dormancy Workshop‚Äô. Bethesda, MD. July 2006.¬†

Ann Chambers, ‚ÄúImaging the Metastatic Process: Preclinical Models andClinical Implications‚ÄĚ. Invited speaker, Usha Mahajani Symposium on Cancer Biology, University of California San Diego/Salk Institute, La Jolla, CA, September 2006.¬†

¬†Ann Chambers, ‚ÄúImaging the Metatatic Process in experimental Models and Clinical Implications‚ÄĚ. Invited Speaker, Ben May Institute for Cancer Research, University of Chicago. Cancer Research Symposium on Frontiers in Metastasis Research, Chicago, October 2006.¬†¬†

Ann Chambers, ‚ÄúBiology of Breast Cancer Metastasis‚ÄĚ. Invited speaker/faculty, 7th Annual New Strategies in Breast Cancer Conference. Philadelphia, PA. April 2007.¬†

Ann Chambers, ‚ÄúHost factors in tumor dormancy‚ÄĚ. Invited speaker, 1st Annual Columbus Breast Cancer Symposium. Columbus, OH. April 2007.¬†

Ann Chambers, ‚ÄúImaging tumor metastasis and dormancy in experimental models‚ÄĚ. Invited speaker, Second International Symposium on Cancer Metastasis and the Lymphovascular System, San Francisco, CA. May 2007.¬†¬†

Ann Chambers and David Nathanson. ‚ÄúAnimal models to study lymphatic and vascular metastasis‚ÄĚ. Meet-the-Professor Breakfast, Second International Symposium on Cancer Metastasis and the Lymphovascular System, San Francisco, CA. May 2007.¬†

Ann Chambers, ‚ÄúNovel imaging approaches for studying tumor metastasis‚ÄĚ. Invited participant, Fondation IPSEN annual meeting on Cancer Science, Metastasis and Invasion. Cancer think-tank. Abazzia de Spineto, Tuscany, Italy. May 2007.¬†

Edward A. Neuwelt, M.D. ‚ÄúImmunotherapy in Brain Tumors: Preclinical and Clinical Studies‚ÄĚ Presented at the annual Blood-Brain Barrier Consortium meeting. Skamania, WA. 2007.¬†

Edward A. Neuwelt, M.D. ‚ÄúMechanisms of Disease: The Blood-Brain Barrier and CNS Tumors‚ÄĚ Henry Ford Hospital, Detroit MI. 2006.