brainmetsbc.org

Center of Excellence Publications, Abstracts and Presentations

A.M. Brufsky, M. Mayer, H.S. Rugo, M. Ulcickas Yood, P.A. Kaufman, E. Tan-Chiu, D. Tripathy, M. Birkner, L. Wang,
M.G. Brammer, D.A. Yardley RegistHER:  Patient Characteristics and Time Course of Central Nervous System Metastases in Patients with HER2+ Metastatic Breast Cancer. ASCO Breast Cancer 2008 Sept 5-7.

Heyn, C., Ronald, J.A., Ramadan, S. S., MacKenzie, L.T., Mikulis, D.J., Palmieri, D., Bronder, J.L., Steeg, P.S., Yoneda, T., MacDonald, I.C., Chambers, A.F., Rutt, B.K. and Foster, P.J.: In vivo tracking of growth and dormancy of solitary cells in a mouse model of breast cancer metastasis to the brain using MRI. Mag. Reson. Med. 56: 1001-1010, 2006.   

Mayer, M.: A patient perspective on brain metastases in breast cancer. Clin. Cancer Res. 13: 1623-1624, 2007.  

Muldoon LL, Soussain C, Jahnke K, Johanson C, Siegal T, Smith QR, Hall WA, Hynynen K, Senter PD, Peereboom DM, Neuwelt EA: Chemotherapy delivery issues in central nervous system malignancy: a reality check. J Clin Oncol. 25(16):2295-305, 2007.    

Palmieri, D., Smith, Q.R., Lockman, P.R., Bronder, J.L., Gril, B., Ahmad, A., Chambers, A.F., Weil, R. J. and Steeg, P.S.: Brain metastasis of breast cancer. Breast Diseases. 26:139-147, 2007.   

Palmieri, D., Chambers, A.F., Felding-Haberman, B., Huang, S. and Steeg, P.S.: The biology of metastasis to a sanctuary site. Clin. Cancer Res. 13: 1656-1662, 2007.  

Palmieri, D., Bronder, J.L., Herring, J.M., Yoneda, T., Weil, R.J., Stark, A.M., Kurek, R., Vega-Valle, E., Feigenbaum, L., Vortmeyer, A.O., Aldape, K. and Steeg, P.S.: Her-2 overexpression increases the metastatic outgrowth of breast cancer cells in the brain. Cancer Res. 67:4190-4198, 2007.     

Abstracts

Brogi, E., Murray, M.P., Nehhozina, T., Akram, M., Cranor, M., Seidman, A. Clinical and pathologic characteristics of brain metastases of breast carcinoma: A study of 74 patients. San Antonio Breast Cancer Symposium, San Antonio, TX. 2006.

Fitzgerald Daniel, Palmieri Diane, Vega-Valle, Jeanne Herring, Steeg Patricia. A xenograft model of brain metastasis of breast cancer: metastatic tumors and the brain microenvironment. American Association of Cancer Research Annual Meeting.Los Angeles, CA. 2007

Gril Brunhilde, Palmieri Diane, Elezar Vega-Valle, Hua k., Herring Jeanne, Gilmer Tona, Rubin Stephen, Steeg Patricia.  Lapatinib Prevents the Metastatic Colonization of EGFR+ and Her-2+ Breast Cancer Cells in the Brain. American Association of Cancer Research Annual Meeting. Los Angeles, CA. 2007.  

Heyn C, Ronald JA, Ramadan SS, Snir JA, Barry AM, MacKenzie LT, Mikulis DJ, Palmieri D, Bronder JL, Steeg PS, Yoneda T, MacDonald IC, Chambers AF, Rutt BK, Foster PJ. In vivo tracking of growth and dormancy of solitary cells in a mouse model of breast cancer metastasis to brain using MRI. 14th Scientific Meeting & Exhibition of the International Society for Magnetic Resonance in Medicine, Seattle,WA. 2006.  

Hunt Mathew, Muldoon Leslie, Palmieri Diane, Steeg Patricia,  Neuwelt Edward. “HER-2 status influences survival in a rat model of brain metastasis from breast cancer”.  Annual Blood-Brain Barrier Consortium Meeting. Skamania Lodge, WA. 2007.And American Association of Cancer Research Annual Meeting. Los Angeles, CA. 2007.  

Mittapalli RK, Manda VK, Smith QR and Lockman PR. Permeability of the fluorophore Texas red is not subject to MRP-2 mediated efflux at the blood-brain barrier. The American Association of Pharmaceutical Scientists, Annual Meeting. San Diego, CA. 2007. 

Mittapalli RK, Fitzgerald A, Manda VK and Lockman PR. A computational approach to predict the blood-brain permeability of fluorescent dyes. The American Association of Pharmaceutical Scientists, Annual Meeting.  San Diego, CA. 2007.  

Newsham Irene and Price Janet. Dissecting the extravasation process of metastatic breast cancer cells using an Electric Cell- Substrate Impedance Sensing (ECIS) assay. Metastasis Research Society Meeting, 2006.  

Palmieri Diane, Bronder Julie, J. Weil Robert, Stark Andreas, Davis Sean, Vega-Valle Eleazar,  Herring Jeane, Toshiyuki Yoneda, Kurek Raffael, Mehdorn H., Meltzer Paul, Steeg Patricia. Preclinical studies in support of the use of Vorinostat (SAHA) for the treatment of brain metastases of breast cancer. American Association of Cancer Research Annual Meeting. Los Angeles, CA. 2007  

Ramadan S, Heyn C, Rutt B, Foster P. Single cell MRI with FIESTA:quantitative benefits of 3T vs. 1.5T. 14th Scientific Meeting & Exhibition of the International Society for Magnetic Resonance in Medicine, Seattle, WA. 2006.   

Ramadan S, MacKenzie L, Steeg P, Palmieri D, Chambers A, Rutt B, Foster P. In-vivo MR tracking of solitary cells as a tool for comparing the metastatic behaviour of two distinct breast cancer cell lines. Imaging Network Ontario 6th Imaging Symposium, Toronto, ON, Canada. 2007.   

Ramadan SS, MacKenzie LT, Steeg PS, Chambers AF, Rutt BK, Foster PJ. In vivo tracking of solitary cells as a tool for comparing the behaviour of two metastatically-distinct cell lines in a mouse model of breast cancer metastasis to the brain. 15th Scientific Meeting & Exhibition of the International Society for Magnetic Resonance in Medicine, Berlin, Germany. 2007.  

Rudraraju Thomas V, Lockman PR, and Smith QR. Blood brain barrier permeability and transport of temozolomide.  The American Association of Pharmaceutical Scientists, Annual Meeting. San Diego, CA. 2007.  

Taskar K, Mittapalli RK, Rudraraju V, Egbert JA, Bohn KA, Gaasch JA, Thomas F, Lockman PR and Smith QR. Improved Left Ventricle Intracardiac injection method for brain metastases of breast cancer in immune compromised mice. Society for Neuroscience Annual Meeting. San Diego, CA. 2007     

Presentations  

Ann Chambers:

8th Annual Symposium of the MIT Koch Institute for Integrative Cancer Research, Applied Biosystems/Life Technologies Leadership in Oncology Lecture, Boston, MA. “Monitoring the fate of cancer cells during metastasis”. June 19, 2009.

 

7th International Symposium on Minimal Residual Cancer, Athens, Greece. “Imaging experimental models of metastasis and dormancy”. September 17, 2009.

 

European Commission Workshop on Trends in Translational Cancer Research, Bergen, Norway.“Does tumour dormancy offer therapeutic strategies?” September 29, 2009

 

The 2010 Miami Winter Symposium, Miami, FL. “Metastatic Inefficiency and Tumor Dormancy”. February 22, 2010.

 

American Association for Cancer Research Annual Meeting, Washington, DC. “Experimental studies of Tumor Metastasis and Clinical Implications”. Plenary speaker. April 21, 2010.

 

MSKCC Brain Tumor Seminar Series, Memorial Sloan-Kettering Cancer Center, New York, NY. “Imaging of experimental models of brain metastasis”. May 3, 2010.

 

The Prostate Centre at Vancouver General Hospital, Vancouver, BC. “Tumor metastasis: Experimental studies and clinical implications”. May 14, 2010.

 

Paula Foster:

Imaging Cancer. Relay for Life, Canadian Cancer Society, St. Catharines, ON, Canada: June 19, 2009.

 

Sue Huang:

Suyun Huang: Transcriptional Regulation of Tumor Growth and Metastases, Emory Winship Elkin lecture series, Winship Cancer Institute, Emory University School of Medicine Atlanta, GA, 3/2010

 

Edward Neuwelt:

Leslie L. Muldoon, Ph.D. “Pre-clinical studies of iron oxide nanoparticles as CNS imaging agents” Presented at the annual Blood-Brain Barrier Consortium meeting, March 2010, Sun River OR.

 

Leslie L. Muldoon, Ph.D. “Vascular effects of an anti-integrin antibody in a rat brain tumor model” AACR Neuro-tumor club presentation, Washington DC, April 2010.

 

Leslie L. Muldoon, Ph.D., and Edward A. Neuwelt, MD. “Antibody-targeted therapy in rat brain tumor models” DOD COE annual meeting, September 2009, Bodega Bay CA.

 

Patricia Steeg and Diane Palmieri:

 Stephan Woditschka, "Molecular Targets for the Prevention of Breast Cancer Brain Metastases", Cancer Prevention Fellowship Program, Fellows Research Meeting, June 2nd, 2010, Rockville, MD.

 

AACR Annual Meeting Educational Session, Brain Metastases, Patricia Steeg

 

 Patricia Steeg 5-15-10 3rd Annual Jean Sindab Triple-Negative Breast Cancer Symposium, Brain Metastases of breast cancer.

 

Patricia Steeg, 3-26-10 Keynote Lecture, Huggins Research Conference, University of Chicago, “Brain metastasis of breast cancer”.

 

Patricia Steeg 3-5-10, Wake Forest University, “Brain metastasis of breast cancer”.

 

Patricia Steeg, 10-4-09, Radiation Research Society, invited talk “Brain metastasis of breast cancer”. Savannah, GA

 

Diane Palmieri, ASCO, Meet the Professor, 2009

 

Brunilde Gril, Molecular mechanism of brain metastasis in ErbB2+ breast cancer. “ErbB2+ driven breast cancer: Old and New.” May 1, 2009 (Taipei, Taiwan), Taiwan Joint cancer conference and GlaxoSmithKline

 

Brunilde Gril, Molecular mechanism of cancer metastasis Meet-the-Expert Session, “ErbB2+driven breast cancer: Old and New.” May 1, 2009 (Taipei, Taiwan), Taiwan Joint cancer conference and GlaxoSmithKline

 

Brunilde Gril, Molecular events in breast cancer progression Breast Cancer Workshop: Molecular Pathobiology of Breast Cancer Experimental Biology, FASEB Meeting, April 24-28, 2010 (Anaheim, California, US)

 

 

Quentin Smith and Paul Lockman:

Quentin Smith, Invited Speaker and Session Chair (June, 2009), 8th International Cerebral Vascular Biology Conference, Sendai, Japan, “Role of active efflux transporter, passive permeability, and parenchymal binding on brain metastasis uptake and distribution of anticancer agents.”

 

Kunal Taskar (Graduate Student in Smith lab), Invited Speaker (June, 2009), 8th International Cerebral Vascular Biology Conference, Sendai, Japan, “Blood-brain barrier permeability and active efflux transport of drugs used in the treatment of metastatic breast

cancer.”

 

Lockman PR. Does Chemotherapy Reach Effective Concentrations for the Treatment of Brain Metastases of Breast Cancer? Medical Rounds – London Health Sciences Center. Invited Seminar and Discussion. London Ontario, Canada. (February, 2010)

 

Lockman PR. Are the Blood-Brain and Blood-Tumor Barriers an Impediment to Drug Delivery? Canadian Institute of Health Research -- Strategic Training Program in Cancer Research & Technology. Translational Seminar Series. Invited Seminar London Ontario Canada (February, 2010)

 

Chambers Ann, “Dormancy and Growth of Tumor Cells in Ectopic Sites”. Invited speaker, Educational Session on ‘Invasion and Metastasis’. American Association for Cancer Research 97th Annual Meeting, Washington, DC, April 2006.   

Chambers Ann, “Biology of Tumor Metastasis and Clinical Implications”. Invited speaker, McGill Cancer Group Seminar Series, McGill University, Montreal, Quebec, Canada, April 2006.   

Chambers Ann, “Tumor Metastasis: Mouse Models and Preclinical Imaging”. Invited speaker, Lawson Imaging Seminar Series, London, Ontario, Canada. April 2006.  

Chambers Ann, “Breast Cancer Metastasis”. Invited speaker, EMBO Conference on Common Molecular Mechanisms of Mammary Gland Development and Breast Cancer Progression. Dublin, Ireland. June 2006.

Ann Chambers, “Imaging the metastatic process in experimental models and clinical simplications”. Invited workshop participant, National Cancer Institutes, NIH, ‘Tumor Dormancy Workshop’. Bethesda, MD. July 2006.   

Chambers Ann, “Imaging the Metastatic Process: Preclinical Models and Clinical Implications”. Invited speaker, Usha Mahajani Symposium on Cancer Biology, University of California San Diego/Salk Institute, La Jolla, CA, September 2006.  

Chambers Ann, “Imaging the Metatatic Process in Experimental Models and Clinical Implications”. Invited Speaker, Ben May Institute for Cancer Research, University of Chicago. Cancer Research Symposium on Frontiers in Metastasis Research, Chicago, October 2006.   

Chambers Ann, “Biology of Breast Cancer Metastasis”. Invited speaker/faculty, 7th Annual New Strategies in Breast Cancer Conference. Philadelphia, PA. April 2007.  

Chambers Ann, “Host factors in tumor dormancy”. Invited speaker, 1st Annual Columbus Breast Cancer Symposium. Columbus, OH. April 2007.  

Chambers Ann, “Imaging tumor metastasis and dormancy in experimental models”. Invited speaker, Second International Symposium on Cancer Metastasis and the Lymphovascular System, San Francisco, CA. May 2007.   

Chambers Ann and Nathanson David, “Animal models to study lymphatic and vascular metastasis”. Meet-the-Professor Breakfast, Second International Symposium on Cancer Metastasis and the Lymphovascular System, San Francisco, CA. May 2007.  

Chambers Ann, “Novel imaging approaches for studying tumor metastasis”. Invited participant, Fondation IPSEN annual meeting on Cancer Science, Metastasis and Invasion. Cancer think-tank. Abazzia de Spineto, Tuscany, Italy. May 2007.  

Lockman Paul, “Drug delivery across the blood-tumor barrier.” Invited Seminar, The University of Texas, MD. Anderson Cancer Center, Cancer Biology Seminar Series. Houston, Tx. February, 2007.  

Lockman Paul, “Permeability at the blood-tumor barrier.” Invited Seminar, Northeastern Ohio University, Colleges of Medicine, Akron, Ohio. 2007.  

Neuwelt Edward, “Immunotherapy in Brain Tumors: Preclinical and Clinical Studies” Presented at the annual Blood-Brain Barrier Consortium meeting. Skamania, WA. 2007.  

Neuwelt Edward, “Mechanisms of Disease: The Blood-Brain Barrier and CNS Tumors” Henry Ford Hospital, Detroit MI. 2006.Copyright BrainMetsBC.orglogo 

Smith Quentin, “Tumors and the Blood-Brain Barrier” 13th Annual Blood-Brain Barrier Consortium Meeting. Sevenson, WA. March 2007.  

Smith Quentin, “Brain Drug Delivery through Carrier-Mediated Transport” 18th Annual Spring Brain Conference. Sedona, Arizona.

Patricia Steeg, “A molecular portrait of breast cancer metastasis to the brain”. Ruth Sager Memorial Lecture, Boston Cancer Research Association. April 2007.  

Steeg Patricia, “Brain metastases of breast cancer”. Keynote speaker, Ben May Institute for Cancer Research, University of Chicago. Cancer Research Symposium on Frontiers in Metastasis Research. October 2006.  

Steeg Patricia, “The role of Her-2 in brain metastasis”. Invited speaker, BRESCOM Breast cancer and metastasis conference. Paris, France. June 2006.  

Steeg Patricia, “New molecular targets for metastatic breast cancer”. Invited speaker, Metastatic Breast Cancer Network, New York, NY. October 2006.